Explify Respiratory provides physicians with a more accurate, more comprehensive, and hypothesis-free approach to diagnosing pneumonia. One test identifies >200 common and rare bacterial, viral, and fungal respiratory pathogens.
Explify Respiratory is useful for:
Explify Respiratory provides physicians with answers even if they don’t know what pathogens to look for.
Over 1 Million hospitalized pneumonia patients per year
Each year, more than one million patients in the United States alone are admitted to the hospital and treated for pneumonia and related symptoms.
In up to 60% of cases, a pathogen is never identified
The laboratory work-up for pneumonia involves multiple tests. Traditional testing methods are limited to specific pathogens and return negative results in up to 60% of pneumonia cases.
Accurately detects > 200 common and rare respiratory pathogens with a single test
Utilizing both DNA and RNA sequencing enables Explify Respiratory to detect and identify bacterial, viral, and fungal pathogens by their unique genetic signatures.
Utilizing next-generation sequencing (NGS) technology and IDbyDNA’s proprietary best-in-class search and data analysis software, Explify Respiratory identifies common pathogens, and rare pathogens clinicians may not have expected to find or thought to test for.
Unlike conventional pneumonia tests which rely on clinicians forming a hypothesis to direct their test ordering, Explify Respiratory provides clinicians with a hypothesis-free approach to respiratory infectious disease diagnosis. It detects bacteria, viruses, and fungi in one assay, and provides interpretive comments by experts to aid clinicians in the management of their patient.
41 specimens from immunocompromised children with respiratory disease resulted negative using a battery of routine laboratory tests (e.g. negative for cultures, stains, EIA, and PCR)
Metagenomic test validation for clinical use that fulfills regulatory requirements poses unique challenges, because standard approaches used for conventional tests may not apply. The validation of Explify Respiratory including; laboratory protocols, data analysis algorithms, reference databases, and the establishment of rigorous quality control metrics was performed based on the framework proposed in The Archives of Pathology and Laboratory Medicine.
Explify Respiratory is currently available to order from ARUP Laboratories. Ordering Explify Respiratory requires no additional processes or steps than ordering other routine tests from ARUP.